Fibrinolysis Inhibition after a Major Standardized Trauma

Lars Bagge Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

Gunnar Carlin Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

Åke Hjelmstedt Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

Herman Högstorp Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

Håkan Jacobsson Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

Jan Modig Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

Tom Saldeen Departments of Forensic Medicine and Anaesthesiology, University of Uppsala and University Hospital, Uppsala, Sweden

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Abstract

The present investigation on 20 patients after total hip replacement surgery has confirmed that the posttraumatic increase of the fibrinolysis inhibition activity (FIA) in serum and plasminogen-depleted serum is due to the primary fibrinolysis inhibitor (PFI,α₂-antiplasmin). This protein exists in at least two forms and it was indicated that PFIα with affinity to immobilized plasminogen, is mainly responsible for the posttraumatic variations of the FIA in plasminogen-depleted serum. PFIβ, the major part of the PFI-related antigen, which has none or low such affinity, displayed weak FIA and relatively small increase after the surgical trauma.

It was established that the posttraumatic increase of the FIA was not derived from the low molecular weight fraction in serum of those patients.

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Fibrinolysis Inhibition after a Major Standardized Trauma

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Fibrinolysis Inhibition after a Major Standardized Trauma

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