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Articles

Enhanced reactivity to malondialdehyde-modified proteins by systemic lupus erythematosus autoantibodies

, , , , , , , , & show all
Pages 247-253 | Received 11 Mar 2009, Accepted 24 Sep 2009, Published online: 29 Apr 2010
 

Abstract

Objective: Evaluation of the reactivity of autoantibodies of systemic lupus erythematosus (SLE) patients directed against malondialdehyde (MDA)-modified catalase, superoxide dismutase (SOD), and different Hep2 protein fractions (hydrophobic, hydrophilic, and nuclear).

Method: Thiol groups and MDA–protein adducts were first assessed among 65 SLE patients and 60 healthy controls. Then, the reactivities of SLE immunoglobulin (Ig)G autoantibodies towards MDA-modified and unmodified proteins were compared using a standard enzyme-linked immunosorbent assay (ELISA).

Results: An increase in the levels of MDA-modified proteins and a decrease in the concentration of thiol groups among SLE patients (p < 0.05) were observed. IgG circulating autoantibodies in the sera of SLE patients exhibited a significant enhanced reactivity (p < 0.05) against catalase and SOD-modified proteins. The same data were observed in the different protein fractions extracted from cultured cells (p < 0.05).

Conclusion: These data reinforce the role of oxidative stress and especially lipid peroxidation products in the progression of SLE disease.

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