Contributors
Yves Artur (Dijon, France)
Olivier Barbier (Quebec City, Quebec, Canada)
Judith Bellemare (Quebec City, Quebec, Canada)
Karl W. Bock (Tübingen, Germany)
Barbara S. Bock-Hennig (Tübingen, Germany)
Stacie M. Bratton (Little Rock, Arkansas, USA)
Patrick Caron (Quebec City, Quebec, Canada)
Michael H. Court (Boston, Massachusetts, USA)
Sylvie Fournel-Gigleux (Vandœuvre-lès-Nancy, France)
Dione A. Gardner-Stephen (Adelaide, South Australia, Australia)
Laurent Grosse (Quebec City, Quebec, Canada)
Chantal Guillemette (Quebec City, Quebec, Canada)
Mario Harvey (Quebec City, Quebec, Canada)
Jean-Marie Heydel (Dijon, France)
Elzbieta J. Holsztynska (Half Moon Bay, California, USA)
élise Houssin (Quebec City, Quebec, Canada)
Dong Gui Hu (Adelaide, South Australia, Australia)
Min Huang (Guangzhou, China)
Shinichi Ikushiro (Toyama, Japan)
Yuji Ishii (Fukuoka, Japan)
Drew R. Jones (Little Rock, Arkansas, USA)
Jenny Kaeding (Quebec City, Quebec, Canada)
Kathleen M. Knights (Adelaide, South Australia, Australia)
Philip Lazarus (Hershey, Pennsylvania, USA)
Anne-Marie Le Bon (Dijon, France)
Ariéle Legendre (Dijon, France)
Eric Lévesque (Quebec City, Quebec, Canada)
Peter I. Mackenzie (Adelaide, South Australia, Australia)
Jacques Magdalou (Vandœuvre-lès-Nancy, France)
Robin Meech (Adelaide, South Australia, Australia)
Vincent Ménard (Quebec City, Quebec, Canada)
Michael J. Miley (Chapel Hill, North Carolina, USA)
Grover P. Miller (Little Rock, Arkansas, USA)
John O. Miners (Adelaide, South Australia, Australia)
Jeffery H. Moran (Little Rock, Arkansas, USA)
Zhimin Ou (Pittsburgh, Pennsylvania, USA)
Mohamed Ouzzine (Vandœuvre-lès-Nancy, France)
Sophie Pâquet (Quebec City, Quebec, Canada)
Martin Perreault (Quebec City, Quebec, Canada)
Anna Radominska-Pandya (Little Rock, Arkansas, USA)
Matt R. Redinbo (Chapel Hill, North Carolina, USA)
Christian P. Strassburg (Hannover, Germany)
Dongxiao Sun (Hershey, Pennsylvania, USA)
Shuso Takeda (Fukuoka, Japan)
Nicolas Thiébaud (Dijon, France)
Jocelyn Trottier (Quebec City, Quebec, Canada)
Mélanie Verreault (Quebec City, Quebec, Canada)
Wen Xie (Pittsburgh, Pennsylvania, USA)
Hideyuki Yamada (Fukuoka, Japan)
Lizi Zhao (Guangzhou, China)
Acronyms
Preface
(Anna Radominska-Pandya) 1
Part I. History of UGTs: Retired UGT Scientists
Chapter I. Memorial for Dr. Kazuta Oguri 3
(Hideyuki Yamada)
Chapter 2. Karl Walter Bock: UDP-glucuronosyltransferases (UGTs): from purification of Ah receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors 5
(Karl Walter Bock, Barbara S. Bock-Hennig)
Chapter 3. Takashi Iyanagi: UGT1 gene complex: from Gunn rat to human 13
(Shinichi Ikushiro)
Part II. Novel UGTs and substrates for glucuronidation reactions
Chapter 1. UGT genomic diversity: beyond gene duplication 22
(Chantal Guillemette, Eric Lévesque, Mario Harvey, Judith Bellemare, Vincent Ménard)
Chapter 2. UGT3A: Novel UDP-glycosyltransferases of the UGT superfamily 43
(Robin Meech, Peter I. Mackenzie)
Chapter 3. Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism 53
(Drew R. Jones, Jeffery H. Moran, Grover P. Miller)
Part III. Tissue expression
Chapter 1. Renal UDP-glucuronosyltransferase and the glucuronidation of xenobiotics and endogenous mediators 60
(Kathleen M. Knights, John O. Miners)
Chapter 2. UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function 71
(Jean-Marie Heydel, Elzbieta J. Holsztynska, Ariéle Legendre, Nicolas Thiébaud, Yves Artur, Anne-Marie Le Bon)
Part IV. UGT regulation
Chapter 1. The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors 95
(Peter I. Mackenzie, Dong Gui Hu, Dione A. Gardner-Stephen)
Chapter 2. Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological funtion and therapeutic potential 106
(Mélanie Verreault, Jenny Kaeding, Patrick Caron, Jocelyn Trottier, Laurent Grosse, élise Houssin, Sophie Pâquet, Martin Perreault, Olivier Barbier)
Chapter 3. The use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies 119
(Zhimin Ou, Min Huang, Lizi Zhao, Wen Xie)
Part V. Structure function of human UGTs
Chapter 1. The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families 128
(Anna Radominska-Pandya, Stacie M. Bratton, Matt R. Redinbo, Michael J. Miley)
Chapter 2. Modulation of UDP-glucuronosyltransferase activity by protein-protein association 140
(Yuji Ishii, Shuso Takeda, Hideyuki Yamada)
Chapter 3. Insights on UGT membrane topology and structure/function 154
(Jacques Magdalou, Sylvie Fournel-Gigleux, Mohamed Ouzzine)
Part VI. Pharmacogenomics
Chapter 1. Gilbert-Meulengracht’s syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? 162
(Christian P. Strassburg)
Chapter 2. Potential role of UGT pharacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors 176
(Philip Lazarus, Dongxiao Sun)
Part VII. Methods
Chapter 1. The prediction of drug glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro–in vivo extrapolation of drug clearance and drug-drug interaction potential 189
(John O. Miners, Peter I. Mackenzie, Kathleen M. Knights)
Chapter 2. Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system 202
(Michael H. Court)
Index 218