Contents
ISSX Overview vi
ISSX Corporate Supporters vii
Upcoming ISSX Meetings viii
Keynote Presentation (Saturday, September 4, 2010)
Drug Transporters: Roles in New Drug Discovery and Development
Abstract: S1 1
Plenary Session and Symposia Presentations (Sunday, September 5, 2010)
Plenary Session 1: Prediction and Mechanisms of Adverse Drug Reactions
Abstracts: S2 – S5 2
Symposium 1: Toxicogenomics and Xenobiotic/Drug Safety: Present Status & Perspectives
Abstracts: S6 – S9 3
Symposium 2: Structure and Function of Drug Metabolizing Enzymes & Transporters
Abstracts: S10 – S13 5
Symposium 3: Clinical Pharmacology of Drug Transport: From Bench to Beside
Abstracts: S14 – S17 7
Symposium 4: Gene Regulation of Drug Metabolizing Enzymes by Nuclear Receptors
Abstracts: S18 – S21 10
Keynote Presentation (Monday, September 6, 2010)
Transporter Mediated Toxicity: The Role of Mitochondrial and Plasma Membrane Transporters
Abstract: S22 12
Symposia Presentations (Monday, September 6, 2010)
Symposium 5: Contemporary Issues in Drug Research and Therapeuticsand Transporters
Abstracts: S23 – S26 12
Symposium 6: Environmental Toxicology and Health
Abstracts: S27 – S30 14
Keynote Presentation (Tuesday, September 7, 2010)
CYP51: A Target for Drug Design
Abstract: S31 17
Plenary Session and Symposia Presentations (Tuesday, September 7, 2010)
Symposium 7: Pharmacogenomics of Cancer Treatment-Emerging Era of Translational Medicine
Abstracts: S32 – S35 17
Symposium 8: Biotechnology: Bioengineering of New Enzymes
Abstracts: S36 – S39 19
Plenary Session 2: Oxidative Stress, DNA Damage, Repair, and Biological Consequences
Abstracts: S40 – S43 22
Symposium 9: Nutrition and Cancer Prevention
Abstracts: S44 – S47 24
Symposium 10: Pharmacoepigenetic and MicroRNA-dependent Control of Drug Metabolism and Action
Abstracts: S48 – S50 26
Plenary Session (Wednesday, September 8, 2010)
Plenary Session 3: Novel Extrahepatic Cytochromes P450s with Endogenous and Exogenous Functions
Abstracts: S51 – S54 27
Finalists for the Predoctoral (Graduate) Poster Awards Competition
(Sunday, September 5 – Tuesday, September 7)
Abstracts: A1 – A6 30
Finalists for the Postdoctoral Poster Awards Competition
(Sunday, September 5 – Tuesday, September 7)
Abstracts: A7 – A12 33
Poster Presentations (Sunday, September 5 – Tuesday, September 7)
Analytical
Abstracts: P1 – P14 37
Bioavailability
Abstracts: P15 – P19 43
Bioinformatics
Abstract: P20 46
Biomarkers
Abstracts: P21 – P24 47
Biotechnology/Nanotechnology
Abstracts: P25 – P26 49
Blood-Brain Barrier
Abstracts: P27 – P28 51
Carcinogenesis/Mutagenesis
Abstracts: P29 – P36 51
Clearance Prediction
Abstracts: P37 – P42 55
Conjugation Reactions and Enzymes
Abstracts: P43 – P59 59
CYPs Endogenous Functions
Abstract: P60 68
Cytochrome P450
Abstracts: P61 – P95 69
Differences in Metabolism (species, gender, age, diseases)
Abstracts: P96 – P102 88
Disposition
Abstracts: P103 – P113 91
DNA Damage and Repair
Abstracts: P114 – P117 98
Drug Discovery and Development
Abstracts: P118 – P142 100
Drug Interaction
Abstracts: P143 – P156 114
Environmental Toxicology
Abstracts: P157 – P174 122
Enzyme Bio-engineering
Abstracts: P175 – P176 131
Enzyme Induction
Abstracts: P177 – P187 132
Enzyme Inhibition/Inactivation
Abstracts: P188 – P208 137
Extrahepatic Metabolism
Abstracts: P209 – P218 149
Gene Expression and Regulation
Abstracts: P219 – P227 154
Genomics/Metabonomics/Proteomics
Abstracts: P228 – P235 159
Hepatocytes
Abstracts: P236 – P247 163
Herbal Medicine-Active Compounds
Abstracts: P248 – P258 170
Herb-Drug Interactions
Abstracts: P259 – P266 176
High Throughput Techniques
Abstracts: P267 – P273 181
In Silico
Abstracts: P274 – P284 184
In Vitro Techniques
Abstracts: P285 – P295 190
Mechanisms of Xenobiotic Toxicities
Abstracts: P296 – P318 197
Metabolic Profiling
Abstracts: P319 – P329 209
Metabolism
Abstracts: P330 – P364 216
Metal ToxicityToxicity
Abstracts: P365 – P369 237
Non-P450 Phase I Enzymes
Abstracts: P370 – P372 239
Nutrition and Chemoprevention
Abstract: P373 241
Oxidative Stress
Abstracts: P374 – P396 241
Pharmacogenetics/ Pharmacoepigenetics
Abstracts: P397 – P420 253
Pharmacokinetics and Pharmacodynamics
Abstracts: P421 – P441 266
Receptors/Nuclear Receptors
Abstracts: P442 – P446 277
Risk Assessment
Abstracts: P447 – P453 280
siRNA/microRNA
Abstracts: P454 – P455 284
Stem Cell Research
Abstract: P456 285
Stereoselective Metabolism
Abstracts: P457 – P459 285
Transporters
Abstracts: P460 – P520 287
Author Index 324
Term Index 343