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Review Article

MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors

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Pages 320-334 | Received 11 Jun 2015, Accepted 22 Jul 2015, Published online: 20 Aug 2015
 

Abstract

Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation.

Declarations of interest

The authors report no declarations of interest.

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