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Hemoglobin
international journal for hemoglobin research
Volume 34, 2010 - Issue 1
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Original Article

Human Immunodeficiency Virus and β-thalassemia Major: A “Competition of Guilt” for Pulmonary Arterial Hypertension. Report of A Case and A Review of the Literature

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Pages 61-66 | Received 28 Jun 2009, Accepted 01 Sep 2009, Published online: 01 Feb 2010
 

Abstract

We report a case of a 43-year-old woman, affected by human immunodeficiency virus (HIV) and β-thalassemia major (β-TM), adequately treated with antiretroviral and transfusion-chelation therapy, that develops progressive right ventricular dysfunction due to severe pulmonary arterial hypertension (PAH), in absence of symptoms. The existence of both HIV and β-TM cardiomiopathy has recently been reported, but how these two diseases have a “competition of guilt” for creating PAH is still to be understood. The main physiopathological principles regarding HIV and β-TM associated PAH are reviewed. The possible interplay between these two different pathologies is discussed.

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