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Hemoglobin
international journal for hemoglobin research
Volume 34, 2010 - Issue 2
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Short Communication

Detection of Hb Constant Spring by a Capillary Electrophoresis Method

Can Liao Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Jian-Ying Zhou Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Xing-Mei Xie Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Jian Li Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Ru Li Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
&
Dong-Zhi Li Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of ChinaCorrespondence[email protected]
Pages 175-178 | Received 02 Nov 2009, Accepted 01 Dec 2009, Published online: 30 Mar 2010
 
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Abstract

Hb Constant Spring [Hb CS; α142, Term→Gln (TAA>CAA in α2)] is the most prevalent nondeletional α-thalassemia (α-thal) anomaly in southern China. In conjunction with α0-thal, it can cause severe Hb H (β4) disease. The present study was done to evaluate the efficiency of two diagnostic methods in detecting Hb CS. Automated high performance liquid chromatography (HPLC) and Sebia Capillarys 2, a capillary electrophoresis method, were applied to blood samples from 21 individuals with Hb CS trait. Of the 21 cases, all (100%) were detected by capillary electrophoresis, whereas only 16 (76.2%) were detected by HPLC. We concluded that the Sebia Capillarys 2 is the preferred method for Hb CS screening.

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