Abnormal Hemoglobins in the Takamatsu District with Emphasis on Epidemiological Characteristics

I. Iuchi Department of Biochemistry and Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama-ken, 701-01, Japan

K. Hidaka Department of Biochemistry and Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama-ken, 701-01, Japan

S. Shimasaki Department of Biochemistry and Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama-ken, 701-01, Japan

S. Shibata Department of Biochemistry and Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama-ken, 701-01, Japan

S. Ueda Department of Biochemistry and Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama-ken, 701-01, Japan

M. Mizushima Kurashiki Central Hospital, Kurashiki, Okayama-ken, 701-01, Japan

H. Aoba Department of Biochemistry and Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama-ken, 701-01, Japan

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Abstract

A hemoglobinopathy survey totaling 22, 921 specimens was conducted for the past three years in the Takamatsu district. The results were reviewed comprehensively from the aspect of population genetics. Six abnormal hemoglobins were discovered in eighteen families including eleven families with Hb Takamatsu (β 120 Lys → Gln) and three families with Hb Yusa (β 21 Asp → Tyr). It was concluded that hemoglobinopathy in the Takamatsu district was characterized by the presence of 1) variants found only in this district (Hb Takamatsu and Hb Yusa), 2) variants which are rare but widely distributed among Japanese, and 3) rare hemoglobins. A homozygote for the Hb Takamatsu gene was reported.

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Abnormal Hemoglobins in the Takamatsu District with Emphasis on Epidemiological Characteristics

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Abnormal Hemoglobins in the Takamatsu District with Emphasis on Epidemiological Characteristics

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