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Hemoglobin
international journal for hemoglobin research
Volume 7, 1983 - Issue 6
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Original Article

Hb S Mobile: A New Genetic Combination

Dr. B. Brimhall Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, 77550
,
Rose G. Schneider Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, 77550
,
Tzu-Bi Shin Department of Biochemistry, School of Medicine Oregon Health Sciences University, Portland, OR, 97201
,
Jaime Zusman Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, 70112
,
R. T. Jones Department of Biochemistry, School of Medicine Oregon Health Sciences University, Portland, OR, 97201
,
W. Byron Smith 1855 San Miguel Drive Walnut Creek, CA, 94596
&
Terry D. King Saint Francis Hospital Monroe, LA, 71201
 show all
Pages 521-531 | Received 06 Jun 1983, Accepted 23 Aug 1983, Published online: 07 Jul 2009
 
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Abstract

The genetic combination of Hb Mobile (β73 Asp→ Val) and Hb S (β6 Glu →Val) was found in a healthy black man whose hemolysate resembles that of Hb S electrophoretically. His mother and sister have Hb AS; the father and brother have Hb A Mobile. No clinical nor hematologic abnormalities were detected in any member of the family. A slightly decreased oxygen affinity associated with Hb Mobile appears to have no clinical significance. Simple methods of differentiating Hb Mobile S from the electrophoretically similar but clinically severe Hb SD Los Angeles are described.

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Related Research Data

Combinations of β chain abnormal hemoglobins with each other or with β-thalassemia determinants with known mutations: influence on phenotype
Source: Oxford University Press (OUP)

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