Hemoglobin A₂ Honai (α₂δ₂90(F6)GLU—VAL): A new Delta Chain Variant

S. Fujita First Department of Internal Medicine, Faculty of Medicine, Ehime University, Ehime, 791-02, Japan

Y. Ohta First Department of Internal Medicine, Faculty of Medicine, Ehime University, Ehime, 791-02, Japan

S. Saito First Department of Internal Medicine, Faculty of Medicine, Ehime University, Ehime, 791-02, Japan

Y. Kobayashi First Department of Internal Medicine, Faculty of Medicine, Ehime University, Ehime, 791-02, Japan

Y. Naritomi First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan

T. Kawaguchi First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan

T. Imamura First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan

Y. Wada Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, 590-02, Japan

A. Hayashi Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, 590-02, Japan

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Abstract

A new slow-moving variant of hemoglobin(Hb) A₂, designated as Hb A₂ Honai, was found to have an amino acid substitution of valine for glutamic acid at position 90(F6) in the δ chain.

Hb A₂ Honai comprised 0.84% of total hemoglobin. Hb A₂ and Hb A were estimated to be 1.30% and 97.85%, respectively. Hb A₂ Honai was observed in 4 members of a family in 3 generations. No hematologic abnormalities were associated with Hb A₂ Honai.

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Hemoglobin A₂ Honai (α₂δ₂90(F6)GLU—VAL): A new Delta Chain Variant

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Hemoglobin A₂ Honai (α₂δ₂90(F6)GLU—VAL): A new Delta Chain Variant