Some Rare Hemoglobin Variants with Altered Oxygen Affinities; Hb Linkoping [β36(C2)Pro→Thr], Hb Caribbean [β91(F7)Leu→Ar6], and Hb Sunnybrook [β 36(C2)Pro→Arg]

Abstract

A few rare hemoglobin variants with altered functional properties have been observed in Canadian subjects with either an erythrocytosis or mild anemia. These variants were Hb Alberta [β101(G3)Glu→Gly], Hb Linkoping [β36(C2)Pro→Thr], a new variant Hb Sunnybrook [β36(CE)Pro→Arg], and Hb Caribbean [β91(F7)Leu→Arg]. Short clinical descriptions of the subjects are given, the characterization of the variants is described in detail (except for Hb Alberta), while data from some functional analyses are provided. Comparisons with previously published data have been made and the unusual chromatographic property of two abnormal β chains in a reversed phase high performance liquid chromatographic system is reviewed.