Hb Las Palms or α₂β₂49(Cd8)Ser→Phe, a Mildly Unstable Hemiglobin Variant

J. J. Malcorra-Azpiazu Departamento de Hematologia-Hemoterapia, Hospital Materno-Infantil, INSALUD Las Palmas, Canary Islands, Spain

H. I. Balda-Aguirre Departamento de Hematologia-Hemoterapia, Hospital Na. Sra. del Pino, INSALUD Las Palmas, Canary Islands, Spain

J. C. Diaz-Chico Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

H. Hu Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

J. B. Wilson Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

B. B. Webber Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

F. Kutlar Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

A. Kutlar Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

T. H. J. Huisman Department of Cell and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-3331, USA

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Abstract

A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45%, respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.

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Hb Las Palms or α₂β₂49(Cd8)Ser→Phe, a Mildly Unstable Hemiglobin Variant

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Hb Las Palms or α2β249(Cd8)Ser→Phe, a Mildly Unstable Hemiglobin Variant

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Hb Las Palms or α₂β₂49(Cd8)Ser→Phe, a Mildly Unstable Hemiglobin Variant