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PRESENTED AT THE INTERNATIONAL CONFERENCE ON HEMOGLOBIN DISORDERS, KUWAIT, February 5–7th, 2011

Iron Chelation Therapy for Transfusional Iron Overload: A Swift Evolution

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Pages 565-573 | Received 06 Mar 2011, Accepted 16 Mar 2011, Published online: 12 Sep 2011
 

Abstract

Chronic transfusional iron overload leads to significant morbidity and mortality. While deferoxamine (DFO) is an effective iron chelator with over four decades of experience, it requires tedious subcutaneous infusions that reflect negatively on patient compliance. The novel oral iron chelators deferiprone (L1) and deferasirox (DFRA) opened new horizons for the management of transfusional siderosis. A large body of evidence is now available regarding their efficacy and safety in various populations and settings. Nevertheless, experience with both drugs witnessed some drawbacks, and the search for an ideal and cost-effective iron chelator continues.

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