157
Views
13
CrossRef citations to date
0
Altmetric
PRESENTED AT THE INTERNATIONAL CONFERENCE ON HEMOGLOBIN DISORDERS, KUWAIT, February 5–7th, 2011

Use of Hormone Replacement Therapy for Correction of High Turnover Bone Disease in Hypogonadal β-Thalassemia Major Patients Presenting with Osteoporosis: Comparison with Idiopathic Premature Ovarian Failure

, &
Pages 653-658 | Received 19 Jul 2011, Accepted 06 Sep 2011, Published online: 10 Nov 2011
 

Abstract

Osteopenia-osteoporosis syndrome (OOS) causes considerable morbidity in 60–80% β-thalassemia major (β-TM) patients. We evaluated the effect of sex hormone replacement therapy (HRT) in β-TM patients with hypogonadism presenting with OOS using premature ovarian failure (POF) for comparative purposes.

We undertook a 10-year prospective study of in 50 β-TM and 375 patients with POF and OOS. All were treated with HRT for 2–5 years. We used dual X-ray absorptiometry (DEXA), and plasma type 1-collagen markers of bone turnover for monitoring of response to therapy.

Our results suggest that prior to HRT, both groups had comparable degrees of OOS. Both groups had significant improvement but the POF group had normalization of spinal T scores following HRT in contrast to the β-TM patients. Femoral T scores did not normalize in both groups. These data indicate for the first time from comparative POF control studies that hypogonadism is not the only cause of OOS in β-TM.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,628.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.