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Hemoglobin
international journal for hemoglobin research
Volume 36, 2012 - Issue 2
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Cord Blood Analysis for Rapid Prenatal Confirmation of Hb Bart’s Disease Using the Sebia Capillary Electrophoresis System

Can LiaoPrenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Jian-Ying ZhouPrenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Xing-Mei XiePrenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Ru LiPrenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
&
Dong-Zhi LiPrenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of ChinaCorrespondence[email protected] [email protected]
Pages 186-191 | Received 30 May 2011, Accepted 03 Aug 2011, Published online: 22 Dec 2011
 
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Abstract

Prenatal diagnosis of severe α-thalassemia (α-thal) diseases is usually performed by DNA analysis. To establish a simple and rapid method, we evaluated the reliability of cord blood hemoglobin (Hb) analysis using an automated capillary electrophoresis (CE) system. Our results demonstrated that analysis of fetal Hb using the Sebia CapillaryS 2 is an effective, accurate and simple alternative for prenatal diagnosis of Hb Bart’s (γ4) disease.

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