A Rare Hb H Disease Due to the – –^SEA and 16.6 kb α-Thalassemia-2 Deletions

Abstract

A large deletional α-thalassemia-2 (α-thal-2) allele was identified in a Thai woman with Hb H disease. The proband has α-thal-1 (SEA type) in conjunction with a 16.6 kb deletion affecting the α2-globin allele. The proband had severe anemia and required a blood transfusion during puerperium.

• Hb H disease
• 16.6 kb Deletion
• α-Thalassemia (α-thal)