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Hemoglobin
international journal for hemoglobin research
Volume 36, 2012 - Issue 4
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Original Article

Hb S [β6(A3)Glu→Val, GAG>GTG] and β-Globin Gene Cluster Haplotype Distribution in Mauritania

, , , , , & show all
Pages 311-315 | Received 26 Sep 2011, Accepted 28 Feb 2012, Published online: 24 May 2012
 

Abstract

Of 1050 Mauritanian blood donors screened from the two main racial groups, i.e., the Moors and Black Africans, 60 were found to carry Hb S [β6(A3)Glu→Val, GAG >GTG], giving a global frequency of 5.71%. The prevalence observed in the Black African Mauritanians (10.69%) is almost five times that found in the Moor group (2.25%). Four of the five main βS haplotypes were detected in this study: Senegal (77.8%), Benin (8.8%), Arab-Indian (5.5%) and Bantu (4.4%). These data showed that Hb S is a serious public health problem in Mauritania. They also confirm the ethnic heterogeneity of the Mauritanian population.

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