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Hemoglobin
international journal for hemoglobin research
Volume 38, 2014 - Issue 2
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Research Article

Hb Ullevaal [β78(EF2)Leu→Val; HBB: c.235C>G], a New Hemoglobin Variant Interfering with Hb A1c Measurement Using a Cation Exchange High Performance Liquid Chromatography Method

Runa M. GrimholtDepartment of Medical Biochemistry, Oslo University Hospital Ullevaal, OsloNorwayCorrespondence[email protected]
,
Åshild A. SudmannDepartment of Medical Biochemistry, Oslo University Hospital Ullevaal, OsloNorway
,
Armin P. PiehlerFürst Medical Laboratory OsloNorway
,
Petter UrdalDepartment of Medical Biochemistry, Oslo University Hospital Ullevaal, OsloNorway
&
Olav KlingenbergDepartment of Medical Biochemistry, Oslo University Hospital Rikshospitalet, OsloNorway
Pages 130-132 | Received 27 May 2013, Accepted 10 Jul 2013, Published online: 25 Nov 2013
 
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Abstract

A new hemoglobin (Hb) variant was detected during Hb A1c measurement. DNA sequencing showed heterozygosity for the single nucleotide substitution (C > G) on the β-globin gene causing an amino acid change [β78(EF2)Leu→Val; HBB: c.235C > G]. The new Hb variant was designated Hb Ullevaal after the hospital at which it was discovered. Heterozygosity for Hb Ullevaal appears to have no clinical significance. However, it interferes with Hb A1c measurement by cation exchange high performance liquid chromatography (HPLC), causing falsely low Hb A1c concentration when using the Tosoh G7 apparatus in variant mode.

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