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Hemoglobin
international journal for hemoglobin research
Volume 38, 2014 - Issue 2
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Research Article

Detection of Hb Anti-Lepore Hong Kong (NG_000007.3: g.63154_70565dup) in Chinese Individuals

Ji-Wu LouPrenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital Dongguan, GuangdongPeople’s Republic of China
,
Yi HePrenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital Dongguan, GuangdongPeople’s Republic of China
,
Yan-Hui LiuPrenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital Dongguan, GuangdongPeople’s Republic of China
,
Bai-Mao ZhongPrenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital Dongguan, GuangdongPeople’s Republic of China
,
Ying ZhaoPrenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital Dongguan, GuangdongPeople’s Republic of China
,
Xiao-Xuan HePrenatal Diagnostic Center, Dongguan Maternal & Children Health Hospital Dongguan, GuangdongPeople’s Republic of China
&
Dong-Zhi LiPrenatal Diagnostic Center, Guangzhou Women & Children Medical Center Guangzhou, GuangdongPeople’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 146-148 | Received 10 Aug 2013, Accepted 11 Sep 2013, Published online: 29 Jan 2014
 
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Abstract

We have identified four Chinese individuals from three unrelated families with raised Hb A2 levels. The anti-Lepore hybrid hemoglobin (Hb) variant was amplified using a pair of primers, 5′ to the β-globin gene Cap site and 3′ to the δ-globin gene polyadenylation site (polyA) region, respectively. Direct sequencing of the βδ fusion products confirmed the anti-Lepore Hong Kong (NG_000007.3: g.63154_70565dup) variant. We found that this anti-Lepore variant is positioned in zone 3 on the capillary electrophoresis system. It may help in differential diagnosis of Hb variants and providing better information in clinical counseling.

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