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Abstract
Hemoglobin (Hb) variants are abnormalities resulting from point mutations in either of the two α-globin genes (HBA2 or HBA1) or the β-globin gene (HBB). Various reports of Hb variants have been described in Iran and other countries around the world. Hb Setif (or HBA2: c.283G>T) is one of these variants with a mutation at codon 94 of of the α2-globin gene that is characterized in clinically normal heterozygous individuals. We here report clinical and hematological findings in two homozygous cases of Iranian origin for this unstable Hb variant.
Acknowledgements
We thank all our colleagues in Molecular Department of the Kariminejad-Najmabadi Pathology & Genetics Centre, Tehran, Iran, for valuable technical assistance and also appreciate the cooperation of the patients who took part in this study.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.