HB Mizuho [β68(E12)LEU-PRO]. Second Occurrence Identified in A Caucasian Child with Hemolytic Anenia and Dense Erythrocyte Inclusions

R. J. Labotka Department of Pediatrics, University of Illinois College of Medicine at Chicago Chicago, IL, 60612, USA

L. N. Vida Department of Pediatrics, University of Illinois College of Medicine at Chicago Chicago, IL, 60612, USA

G. R. Honig Department of Pediatrics, University of Illinois College of Medicine at Chicago Chicago, IL, 60612, USA

Abstract

Hb Mizuho [β68(E12) Leu-Pro] was identified in a child of Italian/Sicilian descent who exhibited severe, transfusion dependent hemolytic anemia which improved following splenectomy. The patient's peripheral blood smear, which prior to splenectomy demonstrated coarse erythrocytic basophilic stippling, showed large, dense erythrocytic hemoglobin inclusions following splenectomy. Whole blood oxygen equilibrium results were consistent with the presence of a hemoglobin component exhibiting increased oxygen affinity with decreased cooperativity. The abnormal p chain was characterized by high performance liquid chromatography analysis of the isopropanol precipitable hemoglobin fraction.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

HB Mizuho [β68(E12)LEU-PRO]. Second Occurrence Identified in A Caucasian Child with Hemolytic Anenia and Dense Erythrocyte Inclusions

Information for

Open access

Opportunities

Help and information

HB Mizuho [β68(E12)LEU-PRO]. Second Occurrence Identified in A Caucasian Child with Hemolytic Anenia and Dense Erythrocyte Inclusions

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature