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Hemoglobin
international journal for hemoglobin research
Volume 14, 1990 - Issue 2
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Original Article

Hb Fukuoka [β2(NA2)HISTYR]: A New Nutation at the 2,3-Diphosphoglycerate Binding Site

T. Harano Department of Biochemistry, Kawasaki Medical School Kurashiki, 701-01, Japan
,
K. Harano Department of Biochemistry, Kawasaki Medical School Kurashiki, 701-01, Japan
,
S. Ueda Department of Biochemistry, Kawasaki Medical School Kurashiki, 701-01, Japan
,
K. Imai Department of Physicochemical Physiology, School of Medicine Osaka University Nakanoshima, Osaka 530, Japan
,
A. Ohkuma Clinical Laboratory Fukuoka-shi Medical Association, Fukuoka 810, Japan
,
Y. Koya Division of Research and Development Tosoh Co., Akasaka, Tokyo, 107, Japan
&
H. Takahashi Division of Research and Development Tosoh Co., Akasaka, Tokyo, 107, Japan
 show all
Pages 199-205 | Received 07 Jun 1989, Accepted 27 Feb 1990, Published online: 07 Jul 2009
 
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Abstract

Two abnormal hemoglobins (Hbs) with a substituted amino acid residue at the 2nd position of the B chain, a part of the 2,3-diphosphoglycerate (2,3-DPG) binding site, have been reported: Hb Deer Lodge (His+Arg) (1) and Hb Okayama (His-Gln) (2). In 1985, we found a new abnormal Hb during assay of Hb A1c and Hb A1 by high performance liquid chromatography (HPLC) in a 38-year-old Japanese female patient suffering from diabetes mellitus. This abnormal Hb was designated Hb Fukuoka [B2(NA2)HisTyr] after the name of the city where the patient lived. Herein, we describe the structural analysis and functional properties of this Hb.

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