The absorption characteristics of bifendate solid dispersion in rat intestinal tissue

Abstract

Aim: Research on bifendate intestinal absorption. Method: The single passed intestinal backflow method was used. Bifendate with different concentrations, bifendate with and without 2,4-dinitrophenol, verapamil, and probenecid, and solid state of bifendate in different systems were studied. Result: Change of concentration and the presence of energy inhibitor, P-glycoprotein inhibitor and multidrug-resistant protein inhibitor did not affect the K_a of bifendate intestinal absorption; there were obvious differences among intestinal absorption of native drug, solid dispersion, and physical mixtures. Conclusion: The result indicated that the intestinal absorption mechanism of bifendate is passive transport. Solid state of bifendate in different systems could affect the intestinal absorption.

Keywords:

• Bifendate
• intestinal absorption
• single-pass intestinal backflow
• solid dispersion

Acknowledgments

The authors thank all the colleagues at the School of Pharmacy in China Pharmaceutical University who have contributed directly or indirectly to this work. We are also grateful to Analysis and Test Centre of China Pharmaceutical University for their kind support.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.