Digestive multienzyme preformulation stability screening using differential scanning calorimetry

Abstract

Differential scanning calorimetry was used for assessing the compatibility in the solid state of pepsin-diastase, pepsin-pancreatin, pancreatin-diastase and pepsin-diastase-pancreatin mixtures using uncoated and Eudragit coated enzymes. The enthalpy change (cal/g) of the resulting thermogram transitions indicated pepsin-diastase and pancreatin-diastase mixtures to be compatible, and pepsin-pancreatin and pepsin-diastase-pancreatin mixtures to be incompatible when uncoated enzymes were used while compatible when coated enzymes with Eudragit were used.