Abstract
A comparison of two new tablet lubricants, sodium stearyl fumarate and glyceryl behenate, was made with magnesium stearate. Physical parameters such as compaction force, ejection force and residual force were investigated and quantified. The effect of these lubricants on a biopharmaceutical parameter such as dissolution rate was also evaluated. The results indicate that where magnesium stearate cannot be used due to problems of compaction, lubrication, stability or for biopharmaceutical reasons, sodium stearyl fumarate should be used as the tablet lubricant of choice, followed by glyceryl behenate as the next alternative