Compatibility Study of Propoxyphene HCL Solid Mixtures Using Differential Scanning Calorimetry

S. L. Law Pharmaceutics Research Laboratory, Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, ROC

W. Y. Lo Copley Pharmaceutical Inc., Boston, Ma, 02127, USA

F. M. Lin Pharmaceutics Research Laboratory, Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, ROC

C. H. Chiang School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, ROC

Abstract

Differential scanning calorimetry was used to investigate the compatibility of propoxyphene HCl-aspirin and propoxyphene HCl-acetaminophen solid mixtures. It was found that the interaction of propoxyphene HCl with aspirin and acetaminophen caused an eutectic mixture. Acetaminophen and propoxyphene HCl showed no degradation in the eutectic mixtures as detected by high performance liquid chromatography.

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Compatibility Study of Propoxyphene HCL Solid Mixtures Using Differential Scanning Calorimetry

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Compatibility Study of Propoxyphene HCL Solid Mixtures Using Differential Scanning Calorimetry

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