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Abstract
Differential scanning calorimetry (DSC) was used to investigate the physico-chemical compatibility between oxprenolol hydrochloride and a number of commonly used tablet and capsule excipients.
Oxprenolol hydrochloride was found to be compatible with starch, Sta-Rx 1500®, Primojel®, Avicel PH 101®, Ac-Di-Sol® and cross-linked PVP. Interactions of oxprenolol hydrochloride with PVP, lactose and the lubricants magnesium stearate and stearic acid were found, although it cannot be conclusively stated that interaction incompatibilities will occur during storage at room temperature.