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Abstract
The controlled release osmo-regulatory sinosules of chlorpromazine hydrochloride (Cpz.OR.CR) were prepared. Cpz.HCl granules containing, powdered sucrose (an osmogent) and soluble lactose were coated employing 12.5% w/v polybutylmethacrylate (PBMA): polyvinylacetate (PVA) (80:20) solution containing varied quantity of channeling agent and plasticizer. At 10:1 core to coat ratio the prepared sinosules released the drug @6.50 mg/h following zero-order kinetics when tested for in vivo performance in Indian dogs and compared with conventional tablet Largactil® 25. The Cpz.OR.CR maintained uniform blood level around the peak level as compared with Largactil® 25 and resulted in significantly higher bioavailability of chlorpromazine.