![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
During product development and scale-up of a generic tablet formulation, the problem of tablet sticking and punch filming was encountered. This report details the various methods that were evaluated to solve this problem and the results achieved. A study was undertaken that examined the use of Chromium Nitride Ion Bombardment, Chromium Electroplating, and alternate cleaning and storage techniques for tablet tooling. The results of the study indicate that the Chromium Nitride treatment significantly improves the tablet adherence problem in compression of the formulation in question. Surface analysis of the tooling was performed to attempt to describe a mechanism for the observed results.