Effect of Amount and Composition of Granulating Solution on Physical Characteristics of Tablets

Abstract

The effect of granulating solution on the physical characteristics and physical stability of tablets was studied based on the response surface methodology. The amount of granulating solution, X1 and its composition ratio, X2, were selected as independent variables. The tablets (100 mg) were manufactured by compressing the mixture of each granule with disintegrant (4 %) and lubricant (0.5 %). A rotary tabletting machine was used. Several characteristics of tablets were well expressed as a quadratic function of X1 and X2 in coded levels. A computer optimization method was applied to the data generated, and a good agreement was observed between the predicted and experimental results in the optimal formula.

Key Words::

• Tablets
• Disintegration Time
• Hardness
• Computer Optimization
• Multiple Regression Analysis
• Experimental Design
• Response Surface
• Granulating Solution