Effect of Colloidal Carriers on the Disposition and Tissue Uptake of Doxorubicin: II. Conjugation with Isobutyl-Cyanoacrylate Nanoparticles

Abstract

The effect of isobutylcyanoacrylate nanoparticles, in the size range of 100–220nm, on the disposition of doxorubicin was investigated. After intravenous injection of drug-containing nanoparticles into rats, the plasma concentration showed an initial rapid rise before a biphasic decline. The rate of the breakdown of the polymer was found to be much slower than the anticipated value. Urine now declined significantly after injection. The concentration of drug in the liver, kidney, lung and spleen was lower than the control and did not increase over time. The low concentration may be attributed to the slow breakdown of the polymer in the body and slow release of the drug associated with the matrix of the carrier. The association of doxorubicin with the nanoparticles alters pharmacokintics of the drug in ways that could provide optimal condition for drug distribution within the systemic circulation and a therapeutic effect with a lesser probability of cardiotoxicity.