Studies on Controlled Release Formulations of Pentazocine Hydrochloride

M. Bhattacharyya Division of Pharmaceutics Pharmaceutics Research Laboratory Department of Pharmaceutical Technology, Jadavpur University, Calcutta, 700 032, INDIA

S. C. Mandal Division of Pharmaceutics Pharmaceutics Research Laboratory Department of Pharmaceutical Technology, Jadavpur University, Calcutta, 700 032, INDIA

B. Sa Division of Pharmaceutics Pharmaceutics Research Laboratory Department of Pharmaceutical Technology, Jadavpur University, Calcutta, 700 032, INDIA

B. K. Gupta Division of Pharmaceutics Pharmaceutics Research Laboratory Department of Pharmaceutical Technology, Jadavpur University, Calcutta, 700 032, INDIA

Abstract

This work embodies studies, performed with micropellet type dosage forms of Pentazocine Hydrochloride (Pz-HCl), using single and composite matrices of Eudragit RS100 (RS) and RL100 (RL). The effects of formulation parameters on various dosage form criteria - namely drug loading, particle size distribution, release profiles etc. have been investigated. Results indicate, that the two polymers can be successfully combined to produce different changes in release kinetics, with simple modifications of coating composition and initial drug loads.

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Studies on Controlled Release Formulations of Pentazocine Hydrochloride

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Studies on Controlled Release Formulations of Pentazocine Hydrochloride

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