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Abstract
An evaluation of different methods of investigating the flow properties of bulk solids has been carried out on four new excipients for direct compression: Maltrin® M 150, Maltrin® M 510, Maltrin® QD M 500 and Maltrin® QD M 550.
Rheological properties of the excipients like parameters from shear test, bulk density, compressibility, flow rate, dynamic angle of repose as well as mean weight and variation coefficients are reported.
Although dynamic angle of repose as well as shear cell method provided similar results for the four maltodextrins under study, we observe a different behavior between the Maltrin® Ml50 and the other excipients under study in the flowmeter, being Maltrin® Ml50 the only excipient which did not flow through any orifice of the flowmeter.
Therefore, our flowmeter, whose results also shows a good correlation with the coefficient of variation of the weight seems to be the most useful technique in providing a parameter which allows assessing better the difference in flowability for similar excipients, as it is the case of these maltodextrins.