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Abstract
The pelletization of lactose, cellulose, polivinylpirrolidone and theophylline was carried out in a 101 high-shear mixer. The effect of impeller speed and the amount of binding solution was investigated on the characteristics of the pellets (percentage of pellets possessing a diameter in the interval 800 to 1250 μm and porous structure). Numerous experiments were performed using the experimental design methodology, in particular a Doehlert and simplex matrix combination.