Preparation and Characterization of Oil-in-Water Type Poly (D, L-Lactic Acid) Microspheres Containing Testosterone Enanthate

Satoru Tsubuku Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan, 360-0111

Shinya Sugawara Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan, 360-0111

Masaharu Miyajima Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan, 360-0111

Masaru Yoshida Department of Material Development, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, Gunma, Japan, 370-1292

Masaharu Asano Department of Material Development, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, Gunma, Japan, 370-1292

Kazuhiko Okabe Department of Urology, School of Medicine, Gunma University, Gunma, Japan, 371-8511

Daishiro Kobayashi Department of Urology, School of Medicine, Gunma University, Gunma, Japan, 371-8511

Hidetoshi Yamanaka Department of Urology, School of Medicine, Gunma University, Gunma, Japan, 371-8511

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Abstract

Poly (D, L-lactic acid) (PLA) microspheres containing testosterone enanthate (ET) were prepared by using an oil-in-water (O/W) emulsion technique. The size distribution of the microspheres obtained could be explained by a log-normal distribution, and as a result, it was found that ET fully incorporates into microspheres even when the drug is loaded at up to 50%. On the other hand, the dissolution behavior of ET from microspheres was strongly dependent on particle size, suggesting that dissolution of the drug from microspheres can be easily controlled by controlling the preparative conditions.

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Preparation and Characterization of Oil-in-Water Type Poly (D, L-Lactic Acid) Microspheres Containing Testosterone Enanthate

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Preparation and Characterization of Oil-in-Water Type Poly (D, L-Lactic Acid) Microspheres Containing Testosterone Enanthate

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