Prospective Study on Combination of Electrical Impedance Scanning and Ultrasound in Estimating Risk of Development of Breast Cancer in Young Women

ABSTRACT

Based on cost-effective ratio, there has not yet been imaging methods suitable for breast cancer screening in young women. The aim of this study was to evaluate the sensitivity and specificity of the combination of electrical impedance scanning (EIS) and ultrasound in identifying breast cancer for young women, to calculate relative risks, and to determine whether there has been some more accurate imaging method used in early detection of breast cancer in young women. A prospective and multicenter clinical study was conducted in young women aged 45 years and under. The young women (583 cases) scheduled for mammary biopsy underwent EIS and ultrasound, respectively. EIS and ultrasound results were compared with final histopathology results. Study end points included sensitivities and specificities of EIS, ultrasound and the combination method, as well as relative probability of breast cancer of positive patients detected by the combination of EIS and ultrasound. Of the 583 cases, 143 were diagnosed with breast cancer. The sensitivities of EIS, ultrasound and the combination method were 86.7% (124/143), 72% (103/143), and 93.7% (134/143); the specificities were 72.9% (321/440), 82.5% (363/440), and 64.1% (282/440), and the relative possibilities of breast cancer for the positive young women detected by EIS, ultrasound, and the combination method were 8.67, 5.77, and 14.84, respectively. The combination of EIS and ultrasound is likely to become an applicable method for early detection of breast cancer in young women.

Keywords: :

• breast cancer
• EIS
• young woman
• early detect

ACKNOWLEDGMENTS

This study was supported by the First and the Second Affiliated Hospital of the Fourth Military University, the 323 Hospital of PLA, the First and Second Affiliated Hospital of Xi’an Jiaotong University, and Zhenghe Hospital of Shaanxi Province.

ABBREVIATIONS

EIS	=	Electrical impedance scanning;
RR	=	relative risk;
PPV	=	positive predictive value;
NPV	=	negative predictive value