Bevacizumab Plus Irinotecan–Based Therapy in Metastatic Colorectal Cancer Patients Previously Treated With Oxaliplatin-Based Regimens

ABSTRACT

Background: Treatment of patients with metastatic colorectal cancer (MCRC) previously exposed to oxaliplatin-based regimen is challenging. Efficacy and toxicity of bevacizumab plus irinotecan–based regimens were assessed in the second-line treatment of MCRC patients. Patients and Methods: Forty patients with a median age of 53years (range, 31–75) were retrospectively evaluated. Patients progressing or relapsing after treatment with oxaliplatin-based regimens were given bevacizumab 5 mg/kg every 2 weeks in combination with irinotecan-based regimens. All patients had previously received oxaliplatin either in the adjuvant setting (n = 8) or for metastatic disease (n = 32). Results: Three patients achieved a complete response (7.5%), 5 partial responses (12.5%) and 14(35%) stable disease resulting in an overall response rate of 20%. Median progression-free survival was 6 months(95% CI, 4.0–8.0) with a median overall survival of 14months (95% CI, 10.2–17.8). One-year survival rate was55.9%. Grade 3–4 toxicities were as follows: neutropenia(n = 15, 37.5%), febrile neutropenia (n = 2, 5%), diarrhea (n = 11, 27.5%), nausea and vomiting (n = 3,7.5%), gastrointestinal perforation (n = 2, 5%), and thromboembolism (n = 2, 5%). Conclusion: Bevacizumab plus irinotecan–based combination chemotherapyis an active and safe treatment option in patients failing oxaliplatin-based therapy.

Keywords: :

• Bevacizumab
• Irinotecan
• Metastatic colorectal cancer
• Oxaliplatin-resistant

ACKNOWLEDGMENT

Authors thank Dr. F. Kabbinavar(University of California, Los Angeles, CA, USA) for hiscritical review of the paper.