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Cancer Investigation Volume 28, 2010 - Issue 10
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ORIGINAL ARTICLECellular and Molecular Biology

Restoration of Fragile Histidine Triad (FHIT) Expression Inhibits Cell Growth and Induces Apoptosis in Cutaneous T-cell Lymphoma Cell Line

Xiangfeng SongDepartment of Immunology, Xinxiang Medical University, Xingxiang,Department of Dermatology, The First Teaching Hospital of Xinxiang Medical UniversityPain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA,Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, PR China.
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Zhongwei TianDepartment of Immunology, Xinxiang Medical University, Xingxiang,Department of Dermatology, The First Teaching Hospital of Xinxiang Medical UniversityPain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA,Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, PR China.
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Shuxing WangDepartment of Immunology, Xinxiang Medical University, Xingxiang,Department of Dermatology, The First Teaching Hospital of Xinxiang Medical UniversityPain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA,Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, PR China.
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Zhenhui PengDepartment of Immunology, Xinxiang Medical University, Xingxiang,Department of Dermatology, The First Teaching Hospital of Xinxiang Medical UniversityPain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA,Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, PR China.
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Jie FengDepartment of Immunology, Xinxiang Medical University, Xingxiang,Department of Dermatology, The First Teaching Hospital of Xinxiang Medical UniversityPain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA,Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, PR China.
Pages 1019-1023 | Published online: 06 Aug 2010
 
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ABSTRACT

To investigate the effects of fragile histidine triad (FHIT) restoration on cell proliferation and apoptosis in human cutaneous T-cell lymphoma cell line, Hut-78, in vitro and in nude mouse. Wild-type FHIT gene was transfected by liposome into the Hut-78 cells. The alteration of cell growth curve and soft agar colony formation was studied in vitro and in nude mice. The FHIT gene was stably expressed in Hut-78 cells after the transfection. Compared with the controls, restoration of FHIT expression inhibited cell growth and induced apoptosis. Tumor formation in vivo was strongly suppressed by FHIT gene restoration. Our data demonstrate restoration of FHIT gene expression inhibit the tumor cell growth and provide an option for the treatment.

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