Advanced search
Publication Cover
Cancer Investigation Volume 28, 2010 - Issue 3
Submit an article Journal homepage
997
Views
6
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLEClinical Translational Therapeutics

Single Agent Vinflunine in the Salvage Treatment of Patients with Castration-Resistant Prostate Cancer: A Phase II Trial of the Sarah Cannon Research Consortium

John D. HainsworthSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
Anthony A. MeluchSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
Cassie M. LaneSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
David R. SpigelSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
Howard A. Burris IIISarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
Jitendra G. GandhiSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
Edward J. CraneSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
,
Michael A. StipanovSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
&
F. Anthony GrecoSarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, Tennessee, USA, Associates in Oncology/Hematology, Chattanooga, Tennessee, USA, Oncology Hematology Care, Cincinnati, Ohio, USA, Chattanooga Oncology and Hematology Associates, Chattanooga, Tennessee, USA.
 show all
Pages 275-279 | Published online: 26 Oct 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m2 every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well tolerated, with myelosuppression as the only frequent toxicity. Vinflunine has a low level of activity in the treatment of refractory metastatic prostate cancer, and should not be further developed for this indication.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.