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Cancer Investigation Volume 27, 2009 - Issue 9
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ORIGINAL ARTICLECellular and Molecular Biology

Upregulated p27kip1 can Downregulate Survivin Expression and Inhibit Telomerase Activity in Gastric Carcinoma Cells

Weiguo ZhangDepartment of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
,
Qiang TongDepartment of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
,
Qingming WuDepartment of Gastroenterology, Affiliated Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China.
,
Shengbao LiDepartment of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
,
Xiaohu WangDepartment of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
&
Qiang WangDepartment of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan, Hubei, China
Pages 898-900 | Published online: 15 Oct 2009
 
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ABSTRACT

Previous study indicated that p27kip1 gene transfer can obviously inhibit the growth of some carcinoma cells. The purpose of this study was to investigate anticarcinoma mechanism of p27kip1. Gastric carcinoma cell strain SGC-7901 was transfected with recombinant adenovirus vector carrying human p27kip1 gene (Ad-p27kip1). Expression of survivin was detected using the western blot method and activity of telomerase was examined by telomeric repeat amplification protocol (TRAP) PCR-ELISA in gastric carcinoma cells. Our results suggest that upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells.

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