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Cancer Investigation Volume 28, 2010 - Issue 1
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ORIGINAL ARTICLECellular and Molecular Biology

Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol

Hong ZhuInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
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Wan-Jing DingInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
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Rui WuInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
,
Qin-Jie WengInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
,
Jian-Shu LouInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
,
Rong-Jia JinInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
,
Wei LuInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 China
,
Bo YangInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 ChinaCorrespondence[email protected] [email protected]
&
Qiao-Jun HeInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China, Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai, 200062 ChinaCorrespondence[email protected] [email protected]
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Pages 23-32 | Published online: 16 Nov 2009
 
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ABSTRACT

The present study demonstrates that the combination of TRAIL/APO-2L and celastrol exerts strong synergistic antiproliferative effect against human cancer cells including ovary cancer OVCAR-8, colon cancer SW620, and lung cancer 95-D, with the combination indices below 0.8. Moreover, the in vivo antitumor efficacy of TRAIL/APO-2L was dramatically increased by celastrol. These enhanced anticancer activities were accompanied by the prompt onset of caspase-mediated apoptosis. Taken together, our data firstly demonstrate the synergistic anticancer capabilities achieved by combining TRAIL/APO-2L and celastrol, and moreover, open new opportunities to enhance the effectiveness of future treatment regimens using TRAIL/APO-2L.

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