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Cancer Investigation Volume 28, 2010 - Issue 1
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ORIGINAL ARTICLEImaging Diagnosis Prognosis

Frequent Allelic Loss of Dkk-1 Locus (10q11.2) is Related with Low Distant Metastasis and Better Prognosis in Head and Neck Squamous Cell Carcinomas

Naoki KataseDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Mehmet GunduzDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Levent Bekir BederDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Esra GunduzDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Mahmoud Al Sheikh AliDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Ryo TamamuraDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Kursat Oguz YaykasliDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Noboru YamanakaDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Kenji ShimizuDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Hitoshi NagatsukaDepartment of Oral pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan, Department of Otolaryngology Head and neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan, Departments of Molecular Genetics and Department of Molecular Biology and Biochemistry,, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
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Pages 103-110 | Published online: 08 Dec 2009
 
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ABSTRACT

Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50%) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.

ACKNOWLEDGMENT

This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to H.N.), 20791337 (to R.T.)], Seed Innovation Research from Japan Science and Technology Agency (to M.G.), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to M.G.) and Astrazeneca Research Grant (to M.G.).

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