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Cancer Investigation Volume 28, 2010 - Issue 6
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ORIGINAL ARTICLECausation and Prevention

ZBTB7 Overexpression Contributes to Malignancy in Breast Cancer

Hongyan QuDepartment of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China
,
Danni QuDepartment of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China
,
Fuhui ChenDepartment of Respiratory Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
,
Zhenyu ZhangDepartment of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China
,
Baogang LiuDepartment of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China
&
Haifeng LiuDepartment of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China
Pages 672-678 | Published online: 15 Apr 2010
 
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ABSTRACT

ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZBTB7 expression levels were significantly correlated with histological grade (p = .023) and marginally inversely correlated with the presence of estrogen receptors (p = .053); its overexpression significantly predicted shorter recurrence-free survival (p = .033). Our results showed that ZBTB7 might be implicated in breast cancer development and may serve as a promising prognostic marker.

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