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Cancer Investigation Volume 29, 2011 - Issue 1
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ORIGINAL ARTICLE: CLINICAL TRANSLATIONAL THERAPEUTICS

Statins Use and Risk for Brain Metastasis From Lung Cancer

D. LeighUniversity of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Family and Community Medicine, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Internal Medicine, Division of Oncology/Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA, Department of Internal Medicine, VA-Nebraska-Western Iowa Healthcare System, Omaha, Nebraska, USA, Department of Internal Medicine, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
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J. EkenUniversity of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Family and Community Medicine, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Internal Medicine, Division of Oncology/Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA, Department of Internal Medicine, VA-Nebraska-Western Iowa Healthcare System, Omaha, Nebraska, USA, Department of Internal Medicine, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
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JR BealUniversity of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Family and Community Medicine, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Internal Medicine, Division of Oncology/Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA, Department of Internal Medicine, VA-Nebraska-Western Iowa Healthcare System, Omaha, Nebraska, USA, Department of Internal Medicine, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
,
AK GantiUniversity of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Family and Community Medicine, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Internal Medicine, Division of Oncology/Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA, Department of Internal Medicine, VA-Nebraska-Western Iowa Healthcare System, Omaha, Nebraska, USA, Department of Internal Medicine, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
&
AE SahmounUniversity of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Family and Community Medicine, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA, Department of Internal Medicine, Division of Oncology/Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA, Department of Internal Medicine, VA-Nebraska-Western Iowa Healthcare System, Omaha, Nebraska, USA, Department of Internal Medicine, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USACorrespondence[email protected]
Pages 68-72 | Published online: 27 Sep 2010
 
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Abstract

Laboratory data suggest an association between statins and risk of brain metastasis (BM) in patients diagnosed with lung cancer. Our retrospective cohort included 252 patients diagnosed with lung cancer and 55 (22%) patients subsequently developed BM. The risk of BM was significantly higher in younger patients (p < .0007). The multivariable Cox model did not show a significant association between statin use and BM from lung cancer (Hazard-Ratio (HR) = 1.20, 95% confidence interval (CI): 0.68–2.13). Future studies should focus on late stage NSCLC and examine the incidence of BM among statin users at the time of death.

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