Advanced search
Publication Cover
Cancer Investigation Volume 29, 2011 - Issue 1
Submit an article Journal homepage
451
Views
57
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE: CELLULAR AND MOLECULAR BIOLOGY

Peroxiredoxin 6 Overexpression Attenuates Cisplatin-Induced Apoptosis in Human Ovarian Cancer Cells

Jhang Ho PakAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, KoreaCorrespondence[email protected]
,
Won Ho ChoiAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
,
Hye Mi LeeAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
,
Won-Duk JooAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
,
Jong-Hyeok KimAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
,
Young-Tak KimAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
,
Yong-Man KimAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
&
Joo-Hyun NamAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan, Korea, and Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
 show all
Pages 21-28 | Published online: 17 Dec 2010
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

We examined the involvement of peroxiredoxin 6 (Prdx 6) in providing chemoprotection against cisplatin cytotoxicity in SKOV-3 ovarian cancer cells. Treatment of SKOV-3 cells with cisplatin-induced cytotoxicity that was associated with increased accumulation of intracellular reactive oxygen species (ROS) and apoptosis mediated by proteolytically activated caspase 3 and 9. Overexpression of Prdx 6 protein or exposure to N-acetylcysteine (NAC) reversed the apoptotic effect of cisplatin by reducing ROS levels and suppressing the caspase signaling pathway. These results indicate that targeting Prdx 6 may sensitize cancer cells to ROS-producing therapeutic treatments, such as anticancer drugs and radiation.

ACKNOWLEDGMENT

This study was supported by a grant (R01-2006-000-11189-0) from the Korea Science and Engineering Foundation (KOSEF) and by a grant (2009-018) from the Asan Institute for Life Sciences, Seoul, Korea. We thank Ju Hyun Moon for the preparation of figures.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.