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Cancer Investigation Volume 29, 2011 - Issue 3
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ORIGINAL ARTICLE: CLINICAL TRANSLATIONAL THERAPEUTICS

Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin

Zhen-Yu HeDepartments of General Surgery and Pathology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Interventional Radiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
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Chuan-Bing ShiDepartments of General Surgery and Pathology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Interventional Radiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
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Hao WenDepartments of General Surgery and Pathology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Interventional Radiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
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Fang-Long LiDepartments of General Surgery and Pathology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Interventional Radiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
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Bao-Lin WangDepartments of General Surgery and Pathology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Interventional Radiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
&
Jie WangDepartments of General Surgery and Pathology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Interventional Radiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCorrespondence[email protected]
Pages 208-213 | Published online: 11 Feb 2011
 
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Abstract

Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.

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