Advanced search
Publication Cover
Cancer Investigation Volume 29, 2011 - Issue 6
Submit an article Journal homepage
179
Views
27
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE: CLINICAL TRANSLATIONAL THERAPEUTICS

Clinical Implications for Girdin Protein Expression in Breast Cancer

Yun LingDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
,
Ping JiangDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
,
Su-Ping CuiDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
,
Ya-Li RenLaboratory of Electron Microscopy, Peking University First Hospital, Beijing, China, and
,
Sai-Nan ZhuDepartment of Biostatistics, Peking University First Hospital, Beijing, China
,
Jing-Ping YangDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
,
Juan DuDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
,
Yan ZhangDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
,
Jian-Ying LiuDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,
&
Bo ZhangDepartment of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China,Correspondence[email protected] [email protected]
 show all
Pages 405-410 | Published online: 07 Jun 2011
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Girdin is highly expressed in breast carcinomas. Suppression of Girdin inhibited breast cancer cell migration. However, the clinical implications of Girdin as a marker are still unclear. Here we examined 80 breast cancer specimens using immunohistochemistry. Overall, positive Girdin staining was 41.25% in all of the cases. Girdin was strongly expressed in tumors of CerbB2-positive breast cancers (p < .05). Cases with both CerbB2- and Girdin-positive expression had a higher histological grade than the others. These findings indicated the closed relationship between breast cancer progression and Girdin expression. Girdin together with CerbB2 might be a new potential marker for breast cancers.

ACKNOWLEDGMENTS

This work was supported by National Natural Science Foundation of China (30570691) to Bo Z, China Postdoctoral Science Foundation (20100470170), and National Natural Science Foundation of China (81072172) to Ping J.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.