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Cancer Investigation Volume 29, 2011 - Issue 7
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ORIGINAL ARTICLE: CAUSATION AND PREVENTION

Risk Estimation for a Malignant Transformation of Oral Lesions by S100A7 and Doc-1 Gene Expression

Jochen WinterDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,Germany
,
Annette PantelisDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,Germany
,
Rudolf ReichDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,Germany
,
Soeren JepsenDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,Germany
,
Jean Piere AllamDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,Germany
,
Natalija NovakDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,Germany
&
Matthias WenghoeferDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn,GermanyCorrespondence[email protected]
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Pages 478-484 | Published online: 08 Jul 2011
 
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Abstract

The objective of this study was the correlation of Doc-1- and S100A7-gene expression in common oral lesions with their cancerous-transformation risk. Biopsies (n = 15 each) of healthy gingiva, irritation fibromas, leukoplakias and Oral squamous cell carcinoma (OSCCs) were obtained, and after RNA-extraction, transcripts of Doc-1 and S100A7 were quantified by RT-PCR. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all lesions. As the extent of Doc-1-inactivation and S100A7-overexpression is correlated with their biological behavior, the combined investigation of both genes could be a promising marker in intraoral lesions to estimate the risk for their malignant transformation.

ACKNOWLEDGMENT

This study was supported by the BONFOR research foundation of the Medical Faculty of the University of Bonn. S. Jepsen (TP2), JP. Allam (TP1), and N. Novak (TP1) were supported by the German Research Foundation (CRU 208).

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