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Cancer Investigation Volume 29, 2011 - Issue 10
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PRECLINICAL

Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

Alessandro LavianoDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,Correspondence[email protected]
,
Alessio Molfino
,
Marilia SeelaenderCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Pauloe, Brazil,
,
Teresa FrascariaDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,
,
Giuseppe Bertiniand Struttura Semplice Dipartimentale Stabilimento Allevatore Fornitore Utilizzatore, Istituti Fisioterapici Ospedalieri (SSD SAFU, IFO), Rome, Italy
,
Cesarina RamacciniDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,
,
Maria Rosa BolleaClinical Nutrition Service, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy,
,
Gennaro Citroand Struttura Semplice Dipartimentale Stabilimento Allevatore Fornitore Utilizzatore, Istituti Fisioterapici Ospedalieri (SSD SAFU, IFO), Rome, Italy
&
Filippo Rossi FanelliDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy,
 show all
Pages 696-700 | Published online: 15 Nov 2011
 
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Abstract

Increased cytokine expression contributes to the pathogenesis of cancer anorexia–cachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n = 8) or saline (equal volume; n = 8). FI and fat-free mass wasting improved in PC rats only (p < .01 vs. controls). Cytokines’ levels decreased in PC rats vs. controls (p < .02). Results suggest that carnitine may ameliorate cancer anorexia–cachexia, via reduction of the inflammatory status.

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