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Cancer Investigation Volume 29, 2011 - Issue 10
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CAUSATION AND PREVENTION

Genetic Polymorphisms of UGT1A7 and Cancer Risk: Evidence From 21 Case–Control Studies

Pei-Hua LuDepartment of Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, China,
,
Min-Bin ChenDepartment of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,
,
Xiao-Yang WuDepartment of Surgical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,
,
Jin-Hua GuDepartment of Medical Laboratory Center, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,
,
Yuan LiuThe Affiliated Eye Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China,
&
Rong-min GuDepartment of Surgery, Nanjing Medical University Affiliated Cancer Hospital of Jiangsu Province, Nanjing, Jiangsu Province, ChinaCorrespondence[email protected]
Pages 645-654 | Published online: 15 Nov 2011
 
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Abstract

The aim of our meta-analysis was to assess the association between UGT1A7 polymorphisms and cancer risk. Case–control studies containing available polymorphic alleles (UGT1A7*1,*2,*3, and*4) and genotypes categorized according to enzymatic activity (High, Intermediate, and Low) were chosen to assess this association. Twenty-one case–control studies were identified. Meta-analysis indicated that UGT1A7 had a significant effect on cancer risk. In subgroup analysis, a significantly increased risk was associated with East Asians, hepatocellular cancer, and colorectal cancer. This meta-analysis suggested that there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.

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